Recently, the Institute of Plant Protection of the Chinese Academy of Agricultural Sciences has cooperated with Huazhong Agricultural University, Sainsbury Laboratory other units to take the lead in mapping out the N-glycosylation-modified proteome map of Magnaporthe grisea revealing the N-glycosylation The molecular mechanism of chemical modification involved in the endoplasmic reticulum quality control system regulating the growth development of plant pathogenic fungi will provide an important candidate target for the prevention control of rice blast also lay a foundation for an in-depth understanding of the pathogenic mechanism of plant pathogenic fungi. The research results were published online in "Public Science Library: Pathogens (PLoS Pathogens)".
According to researcher Liu Wende, rice blast is an important disease that seriously threatens the safety of rice production in the world. Local large-scale epidemics often occur, causing significant losses in agricultural production. Protein N-glycosylation takes place in the endoplasmic reticulum Golgi apparatus, regulates the processes of protein folding transportation in living organisms. However, in plant pathogenic fungi, a large number of proteins modified by N-glycosylation have been identified, their molecular mechanisms regulating the growth pathogenic process of pathogenic bacteria are still unclear. The researchers used a quantitative modification proteomics strategy to map the N-glycosylation modification map of 355 proteins of the 355 proteins of Magnaporthe grisea, found that most of the proteins involved in the endoplasmic reticulum quality control system were Identified as N-glycosylated protein. In-depth analysis revealed that the key protein coding genes Gls1, Gls2, GTB1 Cnx1 of the system are very important for the process of pathogenic bacteria infection cycle hypha growth, conidial development expansion of infection mycelia, Gls1 glycosylation Modification regulates its protein stability endoplasmic reticulum positioning, thereby affecting the biological function of the endoplasmic reticulum quality control system.
The research was supported by projects such as the National Natural Science Foundation of China, the Science Technology Innovation Project of the Chinese Academy of Agricultural Sciences, the Open Project of the State Key Laboratory of Plant Diseases Insect Pest Biology.
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